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Although it is a general postulate that causal effects can exclusively be estimated from experimental studies where an intervention is applied at random, in principle and under certain assumptions (no unmeasured confounders, no measured selection variables and some other, more technical assumptions) it is also possible to estimate bounds on intervention effects for Gaussian variables from observational data, even if the underlying causal structure is not known [ 23 ]. Graphical models are a key element in this method. This result can be extended to binary variables, when interactions in underlying linear regressions are assumed to be absent. For a detailed explanation of this extension and the relation to linear regression, see the Appendix (Additional File HooH Womens Nubuck Studded Winter Warm Snow Boots Black sPoa9Xd

As discussed before, in general intervention effects cannot be determined uniquely by observations alone. In such cases, one obtains a set of possible intervention effects which contains the true effect but might also contain wrong ones. This is a conceptual problem and occurs even if there are infinitely many observations. Using the CHC data, we analyzed the question: "Which ICF category has the most positive effect on the dependent variable General Health Perception (ghp) if it is improved by external intervention (e.g. therapy)?" To this end, we estimated the intervention effect of each ICF category on ghp for each of the 50 data sets obtained from multiple imputation and bootstrapping. Since the estimated intervention effect for each ICF category and in each data set need not be unique, we usually obtained more than 50 estimates of the intervention effect for each ICF category. We then aggregated the estimates for each ICF category using the mean over all estimates for one ICF category. We report on the ranking of the categories according to this measure of effect strength.

Estimation of the skeleton and the intervention effects was done using the R-package "pcalg".

Figure 1

Five largest connected components . All five connected components containing at least three nodes in the skeleton computed on the SCI data.

For sake of brevity, we only present examples of strong associations in the largest connected component (on the left in Figure 1 ). There was a cluster of categories all concerned with relationships. Informal social relationships (d750) was associated with Relating with strangers (d730) , Formal relationships (d740) , Intimate relationships (d770) , and Family relationships (d760) . Formal relationships led to a small structure connecting Complex interpersonal interactions (d720) with Basic interpersonal interactions (d710) . Family relationships (d760) was also associated with a category from the component Body Functions, Emotional functions (b152) . To give another example, one path led from the category Assisting others (d660) to a triangle formed by Preparing meals (d630) , Doing housework (d640) and Caring for household objects (d650) . Assisting others (d660) also led to a triangle formed by Non-remunerative employment (d855) , Remunerative employment (d850) , and Acquiring, keeping and terminating a job (d845) , the latter also being associated with Apprenticeship (d840) .

Returns: The type.

Initialize the relations and submodels for the model type. Normally, this happens automatically, but it doesn't if you're using CoffeeScript and using the syntax instead of the JavaScript equivalent of .

This has advantages in CoffeeScript, but it also means that will not get called. Instead, CoffeeScript generates piece of code that would normally achieve the same. However, is also the method that Backbone-relational overrides to set up relations as you're defining your subclass.

In this case, you should call manually after defining your subclass CoffeeScript-style. For example:

Note: this is a static method. It operates on the model type itself, not on an instance of it.

Returns: A model instance.

Create an instance of a model, taking into account what submodels have been defined.

Note: this is a static method. It operates on the model type itself, not on an instance.

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, and return the model if found. A new model will be created if no model is found, is an object, and is .

Accepted :

A shortcut for that uses . Accepts the same options as (except for ).

A hook to override the matching when updating (or creating) a model. The default implementation is to look up the model by id in the store:

Custom behavior is useful in cases where (a collection of) nested data gets saved to the server. Consider saving the following model:

Normally, whatever you use as server-side logic will respond by creating two animals, and assigning them an id. The response will be used by Backbone-relational to update existing models. However, updating a model starts by looking up the local model with the same id; and in this case, Backbone-relational does not know which local models corresponds to which created animal with an id. A simple fix in this case would be to add a fallback option for the matching by using the animal's species. Do note you'd want to use a more robust method usually, such as using a new model's .

Backbone-relational makes a couple of additional events available to you, on top of the events already found in Backbone.

"remove" "change"

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definition on a model is used to create in instance of a ; either a or a .

Defines a HasOne relation. When defining a Franco Sarto Womens Harlet2 Suede Peep Toe Casual Slingback Sandals Taupe VwHZyDSG
, the default type will be HasMany . However, this can also be set to HasOne to define a one-to-one relation.

HasOne HasMany

Defines a HasMany relation. When defining a reverseRelation , the type will be HasOne .

Backbone.Store is a global model cache. Per application, one instance is created (much like ), which is accessible as .

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